TY - JOUR AU - Salsabila, Sasya Anursyah AU - Sudiono, Janti PY - 2022/08/23 Y2 - 2024/03/28 TI - ANTI-INFLAMMATORY EFFECT OF TAMARILLO PEEL EXTRACT ON IL-6 RAT POST CARRAGEENIN INDUCTION JF - Jurnal Biomedika dan Kesehatan JA - J Biomedika dan Kesehat VL - 5 IS - 2 SE - Original Article DO - 10.18051/JBiomedKes.2022.v5.75-81 UR - https://jbiomedkes.org/index.php/jbk/article/view/213 SP - 75-81 AB - <p><strong>BACKGROUND</strong></p><p>Inflammation is a protective response of the body to injury by releasing pro-inflammatory cytokines; one of them is interleukin-6 (IL-6). The peeled fruit of Tamarillo or terung belanda (<em>Solanum betaceum Cav</em>.) ethanol extract contains flavonoid compounds that have anti-inflammatory potential. This research was conducted to evaluate the anti-inflammatory effect of terung belanda (<em>Solanum betaceum Cav</em>.) peel fruit ethanol extract on carrageenan-induced Wistar strain rat by measuring the IL-6 level.</p><p><strong>METHOD</strong></p><p>Tamarillo (<em>Solanum betaceum Cav</em>.) fruit peel was extracted by maceration methods using 70% ethanol as solvent. The anti-inflammatory was evaluated using 30 rats which were divided into five research groups positive control (diclofenac sodium), negative control (NaCl), and Tamarillo (<em>Solanum betaceum Cav</em>.) fruit peel ethanol extract with a dose of 70mg/kg BW, 140mg/kg BW, and 280mg/kg BW. After the treatment, the rats were injected with carrageenan as an inflammatory inducer. Blood samples were taken at 24, 48 and 72 hours to measure the IL-6 level using the ELISA kit. Statistical analysis used one-way ANOVA with a significant difference as 0.05. RESULTSThe lowest IL-6 levels (13.853 pg/ml) were found in 24 hours at the group of 140 mg/kg BW while in 48 hours at the 280 mg/kg BW group and 72 hours at the 70 mg/kg BW group. In 24 hours, the 140 mg/kg BW group showed lower IL-6 levels than the positive control with a significant difference (p=0.001).</p><p><strong>CONCLUSION</strong></p><p>Tamarillo (<em>Solanum betaceum Cav</em>.) fruit peel ethanol extract is effective as an anti-inflammatory material, especially for 24 hours with a dose of 140 mg/kg BW.</p><p><strong>KEYWORDS</strong>: Tamarillo, <em>Solanum betaceum Cav</em>., Peel Fruit, Ethanol Extract, Carrageenin, IL-6</p> ER -