GLYCEMIC CONTROL EFFECT ON ACID FAST BACTERIA CONVERSION IN DIABETIC PATIENTS WITH TUBERCULOSIS

Abstract

ABSTRACT

Background

Diabetic people have 2-3 times higher risk to have tuberculosis compared to non diabetic people. Immunocompromised condition due to diabetes increases the risk of therapeutic failure and delayed sputum conversion, that may caused by poor glycemic control. This study was conducted to determine the glycemic control effect on AFB conversion in diabetic patients with tuberculosis.

Methods

A cross sectional study has been conducted in 100 diabetic patients with new emerge of pulmonary tuberculosis. All patients were in intensive phase treatment of tuberculosis for 2 months at Bhayangkara R. Said Sukanto’s Hospital. Data collected from medical records were random blood glucose level, percentage of random blood glucose decrement, HbA1C, and also the microscopic AFB sputum smear. Fisher exact test analysis was carried out to determine the effect of random blood glucose level, percentage of blood glucose decrement and HbA1C to AFB smear results using SPSS V25.0 software for windows with significance level 0.05.

Results

The analysis between glycemic control and AFB sputum smear conversion using random blood glucose, percentage of random blood glucose decrement and HbA1C showed p value of 0.000, indicated significanct relationship (p < 0.05) so it showed that glycemic control have effect on AFB sputum smear conversion.

Conclusions

There is a significant relationship between glycemic control with AFB negative conversion in patients with DM and TB. RBG showed the best sensitivity and specificity as glycemic control parameter, compared to others.

Keywords: glycemic control, random blood glucose, HbA1C, RBG decrement, AFB negative conversion, tuberculosis, diabetes melitus