The Risk of Latent Tuberculosis Reactivation in COVID-19 Therapy
DOI:
https://doi.org/10.18051/JBiomedKes.2023.v6.363-372Keywords:
COVID-19, LTBI, reactivation TB, immunosuppressant, corticosteroidAbstract
The high mortality rate among COVID-19 patients in the acute respiratory distress syndrome (ARDS) phase led to the administration of immunosuppressive drugs. Corticosteroids could block inflammation caused by cytokine storm, and prevent pneumonia, edema, fibrosis, and ARDS. Even though it was believed to have beneficial effects, corticosteroids can suppress T CD4+ and CD8+ cell-mediated immunity reaction through decreased IFNγ production thus leading to reactivation of latent Tuberculosis (LTBI). Therefore, the usage of corticosteroids in the ARDS phase of COVID-19 patients should be carefully given; pre-screening of LTBI may be done to avoid Tuberculosis reactivation.
Downloads
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Ghina Mutiara Abas, Fithriyah Sjatha, Yeva Rosana
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
The journal allow the authors to hold the copyright without restrictions and allow the authors to retain publishing rights without restrictions.