Estradiol Towards Sepsis

Estradiol Towards Sepsis

Authors

  • Agustina Br. Haloho Biomedicine Doctoral Program, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia
  • Ramzi Amin Department of Ophthalmology, RSUP Mohammad Hoesin Palembang, South Sumatera, Indonesia
  • Mgs. Irsan Saleh Department of Pharmacology, Faculty of Medicine, Universitas Sriwijaya, Palembang, South Sumatera, Indonesia
  • Krisna Murti Department of Anatomical Pathology, Faculty of Medicine, Universitas Sriwijaya, Palembang, South Sumatera, Indonesia

DOI:

https://doi.org/10.18051/JBiomedKes.2024.v7.104-112

Keywords:

sepsis, estradiol, estrogen, inflammation, inflammatory cytokine

Abstract

Sepsis is an emergency condition as a result of host dysregulation systemic immune response to infection that is related to the end stage of organ dysfunction. Both sepsis and septic shock conditions are the main problems in ICU especially, those that affect millions of people in the whole world every year. Studies in line with immune-neuroendocrine related to sepsis get high attention about factors that play roles in sepsis pathogenesis and prognosis, like correlation to gender, hormones, and other factors. In this case, lots of experimental studies and clinical studies showed that sepsis has significant sexual dysmorphic. The female gender has proven protective against sepsis, meanwhile, males could have worse sepsis because of decreasing immunologic response that mediates cell and cardiovascular function. Estrogen is a hormone in women that plays important roles in not only reproductive function but also non-reproductive function. Physiological estrogen in women is divided into three forms: estrone (E1), estradiol (E2 or 17β- estradiol), and estriol (E3). Several experimental studies in animals showed that estradiol has a protective response when infection occurs. Estrogen generally stimulates cytokine release, induction of HO-1, and restoration of organ function due to sepsis. Potential pathogenesis for this condition is a specific expression of cytokine pro and anti-inflammation. This pathological inflammatory condition is related to gender that is found in surgical patients at the molecular level.

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Author Biography

Agustina Br. Haloho, Biomedicine Doctoral Program, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia

1 Biomedicine Doctoral Program, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia

2Department of Anesthesiology and Intensive Therapy Department, RSUP Mohammad Hoesin Palembang, South Sumatera, Indonesia

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Published

2024-03-31

How to Cite

1.
Haloho AB, Amin R, Saleh MI, Murti K. Estradiol Towards Sepsis. J Biomedika dan Kesehat [Internet]. 2024 Mar. 31 [cited 2024 Jul. 24];7(1):104-12. Available from: https://jbiomedkes.org/index.php/jbk/article/view/359

Issue

Section

Review Article
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