Levels of TGF-β Serum Positively Correlated with Levels of IgM Anti PGL-1 In Household Contacts of Multibacillary Leprosy Patients
Leprosy is a progressive chronic infectious disease. Phenolic glycolipid-1 (PGL-1) is an antigen of Mycobacterium leprae which can trigger the host’s antibody response. Transforming growth factor-β (TGF-β) plays an immunosuppressive role when host exposed to PGL-1 antigen or other M. leprae antigens. This study aims to know correlation of TGF-β levels with IgM anti PGL-1 levels in household contacts of multibacillary leprosy patients.
Analytical observational study with a cross-sectional approach. The sample consisted of 48 household contact subjects and 24 non-household contact subjects aged 15-65 who were selected through consecutive sampling according to the inclusion and exclusion criteria. Samples of 3 milliliters of venous blood were taken, which would then be examined for IgM anti PGL-1 and TGF-β with the ELISA kit. Data analysis was carried out using SPSS version 23, and p-value <0.05 was significant.
The average level of IgM anti PGL-1 in household contact group was 685.46 ± 290.79 u/ml, while in non-household contact group, it was 345.50 ± 206.58 u/ml. The average TGF-β level in household contact groups was 256.69 ± 127.41 pg/ml, while in non-household contact group was 144.85 ± 36.73 pg/ml. This study found a moderate positive relationship (r=0.450, p<0.001) between levels of TGF-β and IgM anti PGL-1.
IgM anti PGL-1 and TGF-β levels in household contacts are higher than in non-household contacts with a significant difference. There is a moderate positive significant relationship between levels of TGF-β and IgM anti PGL-1.
Keywords: leprosy, contacts, IgM anti PGL-1, TGF-β
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Copyright (c) 2023 Putu Yunita Primasari, Luh Made Mas Rusyati, I Gusti Ayu Agung Dwi Karmila, Ketut Kwartantaya Winaya, Nyoman Suryawati, Ni Luh Putu Ratih Vibriyanti Karna
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