CUKA APEL MENURUNKAN BERAT BADAN TIKUS DENGAN OBESITAS

Abstract

BACKGROUND
Obesity has become a global problem in the last ten years. The increasing
incidence of obesity caused an increase number in deaths from various
obesity-related diseases. Pharmacotherapy for obesity that exists today is
limited and has a variety of side effects. Apple cider vinegar is one type
of natural ingredient used by the general public to lose weight. Acetic
acid is an active component of apple cider vinegar that plays important
role in weight loss.

METHODS
This study is an experimental study using experimental animals. Thirtysix Sprague Dawley rats aged 1-2 months were given high-fat diet for 5
weeks. Rats with obesity were divided into 3 groups, the control group,
the P1 group were given apple cider vinegar doses of 0.096mL/100g
twice daily and the P2 group were given apple cider vinegar doses of
0.192mL/100g twice daily. Treatment is given for 4 weeks. Weight and
leftovers food are weighed during treatment period. The final weight
was analyzed with the Kruskal-Wallis test and the weight difference was
analyzed with the one-way ANOVA test followed by the Turkey post hoc
test.

RESULTS
There was no difference in final weight between the 3 groups (p=0.55),
but there was a significant difference in weight before and after treatment
between the control group and the P1 group (p=0.001) and the control
group with the P2 group (p=0.000).

CONCLUSION
Apple vinegar has the potential to be used as an anti-obesity treatment in
obese subjects.

KEYWORDS : Obesity, Apple Cider Vinegar, Weight Loss