JN.1 COVID-19: Variant of interest

JN.1 COVID-19: Variant of interest


  • Husnun Amalia Universitas Trisakti
  • Yasmine Mashabi Department of Clinical Pathology, Faculty of Medicine, Universitas Trisakti, Jakarta, Indonesia




COVID-19, Variant JN.1, spike protein, variant BA.2.86


Corona Virus Disease-19 (COVID-19) is an acute respiratory syndrome caused by the Coronavirus 2 (SARS-CoV-2) virus. WHO groups the SARS-CoV-2 virus into two categories, namely a variant of interest (VOI) and a variant of concern (VOC). The VOI category is given if there is a new mutation with predictable phenotypic implications and must be fulfilled by one mutation that causes local transmission or causes multiple clusters or is detected in several countries. In September 2023, a new variant of COVID-19 was detected in the United States, namely JN.1 as VOI. This variant is a variation of the BA.2.86 variant with the only difference being the mutation of 1 spike protein, namely the addition of the L455S protein in the JN.1 variant. This variant has the potential to evade the immune system. Globally, there has been a rapid increase in the number of sufferers, especially in 3 WHO regions, namely America (AMR), West Pacific (WPR) and Europe (EUR). However, the effectiveness of the monovalent vaccine against this variant can still protect sufferers. Several studies show that the risk of hospitalization is low in the case of elderly and young patients.


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Author Biography

Husnun Amalia, Universitas Trisakti

Departemen Ilmu Penyakit Mata, Fakultas Kedokteran Universitas Trisakti, Indonesia




How to Cite

Amalia H, Mashabi Y. JN.1 COVID-19: Variant of interest. J Biomedika dan Kesehat [Internet]. 2023 Dec. 31 [cited 2024 Mar. 5];6(3):261-3. Available from: https://jbiomedkes.org/index.php/jbk/article/view/474




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